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8 mg of colchicine administered over 1 hour was as effective as 4.

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renal impairment pharmacokinetics of colchicine in patients with mild and moderate renal impairment is not known.

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you should not use this medicine if you have a life-threatening heart rhythm disorder, a history of long qt syndrome, low levels of potassium in your blood, if you have ever had jaundice or liver problems caused by taking clarithromycin, or if you have liver or kidney disease and are also taking colchicine.

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